How the pancreatic endocrine hormones glucagon and insulin work antagonistically to maintain homeostasis in the body and a discussion of negative feedback.

Energy, in the form of sugar, is transported in the blood. It is carried throughout the body and into all cells to produce ATP. ATP is needed for all cellular activity of the body. It is essential that the blood can maintain the body's fuel at a constant level (homeostasis) regardless of how long it has been since the last meal. There are three main organs that regulate the control of blood sugar: the pancreas, …

…carbohydrate meal). Insulin carries out its function and starts to bring blood glucose concentrations back down to normal, then this removes the stimulus that tells the beta cells to secrete the insulin in the first place. As a result, the beta cells become less and less stimulated and so the rate of secretion of insulin declines in parallel to the rate of decline in blood glucose concentration. This mechanism is referred to as negative feedback.